key points passmedicine (part-G)
Causes of villous atrophy (other than coeliacs): tropical sprue, Whipple's, lymphoma, hypogammaglobulinaemia Central retinal vein occlusion - sudden painless loss of vision, severe retinal haemorrhages on fundoscopy Cephalosporins are now the treatment of choice for Gonorrhoea Cephalosporins, not just clindamycin, are strongly linked to Clostridium difficileCetuximab - monoclonal antibody against the epidermal growth factor receptor Chickenpox exposure in pregnancy - first step is to check antibodies Chickenpox exposure when pregnant - if not immune give VZIG Chronic myeloid leukaemia - imatinib = tyrosine kinase inhibitor Ciclosporin + tacrolimus - MOA: inhibit calcineurin thus decreasing IL-2 Ciclosporin - decreases IL-2 release by inhibiting calcineurin Ciclosporin side-effects: everything is increased - fluid, BP, K+, hair, gums, glucose Ciprofloxacin – tendinopathy Cisplatin is associated with hypomagnesaemia Cisplatin may cause peripheral neuropathy Clopidogrel inhibits ADP binding to platelet receptors Clozapine is no longer used first-line due to the risk of agranulocytosis Cluster headache - acute treatment: subcutaneous sumatriptan + 100% O2 Coeliac disease - tissue transglutaminase antibodies first-line test Cohort studies - relative risk Collapse + ARF → rhabdomyolysis - treat with IV fluids |
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