Faraz Ahmed guide to MRCP

Colorectal cancer screening - PPV of FOB = 5 - 15% Combined B- and T-cell disorders: SCID WAS ataxic (SCID, Wiskott-Aldrich syndrome, ataxic telangiectasia) Complete heart block causes a variable intensity of S1 Complete heart block following a MI? - right coronary artery lesion Complete heart block following an inferior MI is NOT an indication for pacing, unlike with an anterior MI Congenital heart disease:- cyanotic: TGA most common at birth, Fallot's most common overall acyanotic: VSD most common cause  Congenital rubella:- sensorineural deafness congenital cataracts Congenital toxoplasmosis:- cerebral calcification chorioretinitis Contraindications to lung cancer surgery include SVC obstruction, FEV < 1.5, MALIGNANT pleural effusion, and vocal cord paralysis Correlation:- parametric (normally distributed): Pearson's coefficient non-parametric: Spearman's coefficient Cushing's syndrome - hypokalaemic metabolic alkalosis Cyclophosphamide - haemorrhagic cystiti

Causes of villous atrophy (other than coeliacs): tropical sprue, Whipple's, lymphoma, hypogammaglobulinaemia Central retinal vein occlusion - sudden painless loss of vision, severe retinal haemorrhages on fundoscopy Cephalosporins are now the treatment of choice for Gonorrhoea Cephalosporins, not just clindamycin, are strongly linked to Clostridium difficile Cetuximab - monoclonal antibody against the epidermal growth factor receptor Chickenpox exposure in pregnancy - first step is to check antibodies Chickenpox exposure when pregnant - if not immune give VZIG Chronic myeloid leukaemia - imatinib = tyrosine kinase inhibitor Ciclosporin + tacrolimus - MOA: inhibit calcineurin thus decreasing IL-2 Ciclosporin - decreases IL-2 release by inhibiting calcineurin Ciclosporin side-effects: everything is increased - fluid, BP, K + , hair, gums, glucose Ciprofloxacin – tendinopathy Cisplatin is associated with hypomagnesaemia Cisplatin may cause peripheral neuropathy Clopidogrel inhibits A

CLL - treatment: Fludarabine, Cyclophosphamide and Rituximab (FCR) CLL is caused by a monoclonal proliferation of B-cell lymphocytes CML - Philadelphia chromosome - t(9:22) COPD - LTOT if 2 measurements of pO2 < 7.3 kPa COPD - reason for using inhaled corticosteroids - reduced exacerbations COPD - still breathless despite using inhalers as required? FEV1 > 50%: LABA or LAMA FEV1 < 50%: LABA + ICS or LAMA CT head showing temporal lobe changes - think herpes simplex encephalitis CTPA is the first line investigation for PE according to current BTS guidelines CYP3A4 is the most common and important cause of P450 drug interactions Calcium channel blockers - side-effects: headache, flushing, ankle oedema Calcium channel blockers are now preferred to thiazides in the treatment of hypertension Cancer patients with VTE - 6 months of LMWH Carbon monoxide poisoning - most common feature = headache Case-control studies - odds ratio Cat scratch disease - caused by Bartonella henselae Caus

Blood pressure target (based on clinic readings) for patients < 80 years - 140/90 mmHg Bosentan - endothelin-1 receptor antagonist Breakthrough dose = 1/6th of daily morphine dose Breast feeding is acceptable with nearly all anti-epileptic drugs Bronchiectasis: most common organism = Haemophilus influenzae Brush border enzymes: maltase: glucose + glucose sucrase: glucose + fructose lactase: glucose + galactose Bupropion: contraindicated in epilepsy Burkitt's lymphoma - c-myc gene translocation Burkitt's lymphoma is a common cause of tumour lysis syndrome Burning thigh pain - ? meralgia paraesthetica - lateral cutaneous nerve of thigh compression CKD on haemodialysis - most likely cause of death is IHD CKD: only diagnose stages 1 & 2 if supporting evidence to accompany Egfr CLL - immunophenotyping is investigation of choice Blisters/bullae:- no mucosal involvement (in exams at least*): bullous Pemphigoid mucosal involvement: pemphigus vulgaris