KEY POINTS FOR MRCP PART-I AND PART-II (Part A)

KEY POINTS FOR MRCP PART-1 AND PART 2 Wilson's disease - serum caeruloplasmin is decreased 'Fasciculations' - think motor neuron disease 1mg prednisolone = 4mg hydrocortisone 24hr oesophageal pH monitoring is gold standard investigation in GORD 4% of patients with UC have PSC, 80% of patients with PSC have UC AIP - porphobilinogen deAminase; PCT - uroporphyrinogen deCarboxylase Chorea is caused by damage to the basal ganglia, in particular the Caudate nucleus Drusen = Dry macular degenerationDystrophia myotonica - DM1:-Distal weakness initially autosomal Dominant

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DiabetesDysarthria

 Streptococcus bovis endocarditis is associated with colorectal cancer Streptococcus pneumoniae is associated with cold sores

 E. coli is the most common cause of travellers' diarrhoea H. pylori eradication:PPI + amoxicillin + clarithromycin, or
PPI + metronidazole + clarithromycin Saccharopolyspora rectivirgula causes farmer's lung, a type of EAA ACE inhibitors have reduced efficacy in black patients and are therefore not used first-line ADPKD type 1 = chromosome 16 = 85% of cases ADPKD type 2 = chromosome 4 = 15% of cases ATN or prerenal uraemia? In prerenal uraemia think of the kidneys holding on to sodium to preserve volume Absence seizures - good prognosis: 90-95% become seizure free in adolescence Absolute risk reduction = (Control event rate) - (Experimental event rate)

	Acne rosacea treatment:mild/moderate: topical metronidazole severe/resistant: oral tetracycline

 Streptococcus bovis endocarditis is associated with colorectal cancer Streptococcus pneumoniae is associated with cold sores

 E. coli is the most common cause of travellers' diarrhoea