Last Min Clinical Hematology and oncology Passmedicine (part B)

-
Patients with Sjogren's syndrome have an increased risk of lymphoid malignancies
Philadelphia translocation, t(9;22) - good prognosis in CML, poor prognosis in AML + ALL
Polycythaemia rubra vera - JAK2 mutation
Polycythaemia rubra vera - around 5-15% progress to myelofibrosis or AML
Polycythaemia rubra vera is associated with a low ESR
Rasburicase - a recombinant version of urate oxidase, an enzyme that metabolizes uric acid
to allantoin
Screening for haemochromatosis
 general population: transferrin saturation > ferritin
 family members: HFE genetic testing
TTP - plasma exchange is first-line
Taxanes (e.g. Docetaxel) prevent microtubule disassembly
Tear-drop poikilocytes = myelofibrosis
Trastuzumab (Herceptin) - cardiac toxicity is common
Trimethoprim may cause pantcytopaenia
Venous thromoboembolism - length of warfarin treatment
 provoked (e.g. recent surgery): 3 months
 unprovoked: 6 months
Vincristine - peripheral neuropathy
Blood film abnormalities
Tear-drop poikilocytes - myelofibrosis
Drug adverse effects
Primaquine may cause haemolysis in patients with G6PD deficiency
Drug mechanism of action
Imatinib - inhibitor of the tyrosine kinase associated with the BCR-ABL
defect
Haemolytic anaemia
Extravascular haemolysis - warm autoimmune haemolytic anaemia

Comments

Post a Comment

Popular posts from this blog

KEY points passmedicine for part-1 and part-2 (part-c)

-
Ankylosing spondylitis - x-ray findings: subchondral erosions, sclerosis and squaring of lumbar vertebrae Ankylosing spondylitis features - the 'A's Apical fibrosis Anterior uveitis  Aortic regurgitation Achilles tendonitis AV node block Amyloidosis  Anorexia features:- most things low G's and C's raised: growth hormone, glucose, salivary glands, cortisol, cholesterol, carotinaemia Anti-Jo-1 antibodies are more common in polymyositis than dermatomyositis Anti-cyclic citrullinated peptide antibodies are associated with rheumatoid arthritis Anti-ribonuclear protein (anti-RNP) = mixed connective tissue disease Antibiotic prophylaxis reduces mortality in cirrhotic patients with gastrointestinal bleeding Anticipation in trinucleotide repeat disorders = earlier onset in successive generations Antidiuretic hormone (ADH) - site of action = collecting ducts Antiphospholipid syndrome in pregnancy: aspirin + LMWH Antiphospholipid syndrome: (paradoxically) prolonged APTT +
Read more

KEY points pass medicine for part -1 and part-2 (part-b)

-
H. pylori eradication: PPI + amoxicillin + clarithromycin, or PPI + metronidazole + clarithromycin  Saccharopolyspora rectivirgula causes farmer's lung, a type of EAA  ACE inhibitors have reduced efficacy in black patients and are therefore not used first-line  ADPKD type 1 = chromosome 16 = 85% of cases  ADPKD type 2 = chromosome 4 = 15% of cases  ATN or prerenal uraemia? In prerenal uraemia think of the kidneys holding on to sodium to preserve volume  Absence seizures - good prognosis: 90-95% become seizure free in adolescence  Absolute risk reduction = (Control event rate) - (Experimental event rate)  Acne rosacea treatment: mild/moderate: topical metronidazole severe/resistant: oral tetracycline Acromegaly: increased sweating is caused by sweat gland hypertrophy Activated protein C resistance (Factor V Leiden) is the most common inherited thrombophilia Acute angle closure glaucoma is associated with hypermetropia, where as primary open-angle glaucoma is associated wit
Read more